Best Berberine Supplements on iHerb (2026): Top Picks + Comparison Table
If you’re searching for the best berberine supplement on iHerb, you’re not alone. Berberine has become one of the most popular plant compounds for people focused on metabolic health, and iHerb offers dozens of options—different forms, doses, and “absorption” claims.
In this guide, I’ll show you what matters most when choosing a berberine supplement, then share top iHerb picks with a comparison table you can fill in from product labels.
Disclaimer: This content is for educational purposes and is not medical advice.
Quick Answer: My Top iHerb Picks (Short List)
- Best overall value (classic berberine HCl): California Gold Nutrition – Berberine HCl (500 mg)
- Best “absorption-focused” option (phytosome): Solaray – Berberine Phytosome (550 mg)
- Best softgel formula: NOW Foods – Berberine Glucose Support (400 mg/softgel)
- Best premium brand option: Thorne – Berberine (200 mg/capsule)
- Best budget capsule: Source Naturals – Berberine (500 mg)
- Best with extra add-ons: Codeage – Berberine + ALA (500 mg)
Note: “Best” depends on your goal, tolerance, and budget. Always check the label and talk to a clinician if you take medications.
What to Look for in a Berberine Supplement
1) Form matters: Berberine HCl vs Phytosome
- Berberine HCl is the classic form found in many capsules (often 400–500 mg). It’s usually the best value.
- Phytosome / “enhanced absorption” products are marketed to improve absorption by binding berberine to phospholipids; some products explicitly call this out on their label/marketing .
2) Dose per serving (and servings per day)
Some products are 500 mg per capsule, while others are lower per capsule but recommend multiple servings per day. For example, NOW Foods’ product lists 400 mg per softgel with a suggested use of 1 softgel 3 times daily . Always compare “mg per day,” not just “mg per capsule.”
3) Quality signals
Look for:
- Clear Supplement Facts panel (no “proprietary blend” for the active dose)
- GMP / quality testing claims (and ideally a published test program—some iHerb in-house programs exist depending on brand)
4) Safety & interactions
Berberine can interact with medications via effects on drug-transport and metabolism pathways (e.g., P-gp and CYP enzymes), and caution is commonly advised for pregnancy/breastfeeding . If you use diabetes meds, blood pressure meds, blood thinners, or other prescriptions—ask your clinician first.
Comparison Table (Fill in from Labels)
How to use: Open each iHerb product → “Supplement Facts” → copy the numbers into this table.
| Product | Form | Berberine per serving | Capsules/Softgels per serving | Servings per container | Notes | Best for |
|---|---|---|---|---|---|---|
| California Gold Nutrition – Berberine HCl | HCl | 500 mg | 1 | (fill) | Straightforward formula | Best overall value |
| Solaray – Berberine Phytosome | Phytosome | 550 mg | 1 | (fill) | Marketed for enhanced absorption | Absorption-focused pick |
| NOW Foods – Berberine Glucose Support | HCl | 400 mg | 1 (per serving) | (fill) | Suggested 3x daily | Softgel fans |
| Thorne – Berberine | (see label) | 200 mg | 1 | (fill) | Lower dose capsule | Premium brand lovers |
| Source Naturals – Berberine | (see label) | 500 mg | 1 | (fill) | Simple budget capsule | Best budget |
| Codeage – Berberine + ALA | Blend | 500 mg | 2 | (fill) | Includes ALA | “All-in-one” formula |
Product Reviews (One Section Per Pick)
1) California Gold Nutrition – Berberine HCl (Best Overall Value)
Overview: A clean, classic berberine HCl option at a common “standard” dose.
Features: 500 mg per serving
Pros: Simple formula; easy to compare; great starting point.
Cons: No “absorption technology” if you specifically want that.
Pricing: (add your price here from iHerb)
Best for: Most beginners who want straightforward berberine.
2) Solaray – Berberine Phytosome (Best Absorption-Focused Pick)
Overview: A phytosome product marketed for improved absorption.
Features: 550 mg per serving
Pros: Great if you prefer “enhanced absorption” positioning.
Cons: Often more expensive per mg than basic HCl.
Pricing: (fill)
Best for: People who want an “absorption-focused” option.
3) NOW Foods – Berberine Glucose Support (Best Softgel Option)
Overview: Softgel format; dose is 400 mg per serving.
Features: 400 mg per softgel
Pros: Softgels can be easier to swallow for some.
Cons: Suggested use is multiple times daily (label suggests 3x/day)
Pricing: (fill)
Best for: Anyone who prefers softgels or split dosing.
4) Thorne – Berberine (Best Premium Brand)
Overview: A well-known practitioner brand with a lower per-capsule dose.
Features: 200 mg per capsule
Pros: Trusted brand; easy to fine-tune dose by capsule count.
Cons: Lower mg per capsule may raise cost per “daily mg.”
Pricing: (fill)
Best for: People who want a premium brand and flexible dosing.
5) Source Naturals – Berberine (Best Budget Capsule)
Overview: Simple berberine capsule with a standard dose.
Features: 500 mg per serving
Pros: Usually competitive pricing; no fluff.
Cons: Basic formula (no extras).
Pricing: (fill)
Best for: Budget shoppers who want a straightforward capsule.
6) Codeage – Berberine + ALA (Best With Add-Ons)
Overview: Berberine combined with alpha-lipoic acid (ALA).
Features: Berberine 500 mg; serving size 2 capsules
Pros: Convenient combo if you already want ALA.
Cons: Not ideal if you prefer single-ingredient supplements.
Pricing: (fill)
Best for: People who like combo formulas.
How to Take Berberine (Practical Notes)
- Start low if you’re sensitive and increase gradually.
- Many people split doses with meals (follow the label).
- If you take medications, check interactions—berberine may affect drug transport/metabolism pathways .
Q1: What is the best berberine supplement on iHerb?
A: For most people, a simple berberine HCl product with a clear label and good value is the best starting point. If you prefer absorption-focused products, consider a phytosome option.
Q2: Berberine HCl vs phytosome—what’s the difference?
A: Berberine HCl is the classic form. Phytosome products are marketed to improve absorption by binding the ingredient to phospholipids .
Q3: Can berberine interact with medications?
A: Yes. Reviews note potential interactions through mechanisms like P-gp transporters and CYP enzymes . Talk to a clinician if you take prescriptions.
Q4: Who should avoid berberine?
A: People who are pregnant/breastfeeding are often advised to avoid it, and anyone on medications should check safety first .
Q5: How do I choose the right dose?
A: Compare “mg per day” based on the label’s serving size and suggested use. Some formulas require multiple servings daily .